Kenichi Hiramatsu Selected Research

T140 peptide

1/2007	Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents.
6/2006	Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs.
7/2004	Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent.
8/2003	T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer.
5/2002	Certification of the critical importance of L-3-(2-naphthyl)alanine at position 3 of a specific CXCR4 inhibitor, T140, leads to an exploratory performance of its downsizing study.
3/2002	Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the betaII'-turn moiety.

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Kenichi Hiramatsu Research Topics

Disease

5	Neoplasms (Cancer) 01/2007 - 08/2003
3	Neoplasm Metastasis (Metastasis) 06/2006 - 08/2003
2	Rheumatoid Arthritis 06/2006 - 07/2004
2	Infections 05/2002 - 03/2002
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2007
1	Hypersensitivity (Allergy) 07/2004
1	Experimental Arthritis 07/2004
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2004
1	Breast Neoplasms (Breast Cancer) 08/2003

Drug/Important Bio-Agent (IBA)

6	T140 peptideIBA 01/2007 - 03/2002
4	Peptides (Polypeptides)IBA 01/2007 - 03/2002
4	Chemokine ReceptorsIBA 07/2004 - 03/2002
2	HIV Fusion InhibitorsIBA 01/2007 - 07/2004
2	4-fluorobenzoyl-TN-14003IBA 07/2004 - 08/2003
1	CXCR4 Receptors (CXCR4 Receptor)IBA 07/2004
1	Mitogen-Activated Protein KinasesIBA 01/2004
1	TN14003IBA 01/2004
1	Laminin (Merosin)IBA 01/2004
1	Neutralizing AntibodiesIBA 08/2003
1	LigandsIBA 08/2003
1	AcidsIBA 05/2002

Therapy/Procedure

2	Subcutaneous Injections 07/2004 - 08/2003
1	Therapeutics 08/2003